For some people they do, others it doesn't. Some people even lose some weight. It just all depends on your bodies metabolism.

I didn't I'm actually smaller now been taking Biktarvy since 2020..But in this last year I've been admitted into the hospital twice and I also had 2 teeth with abscesses at the same time.. Couldn't eat any solid food for maybe 4-6mnths so I've gone from 220 solid to 140ish I'm 5'5" 41yrs but this has been the best med regimen I've ever been on..Went from taking 5-6 different pills a day to just 1 pill a day..But I've been pov since i was 17 never been sick or anything up until a couple yrs ago after I had my bout with depression

When I was on issentress it made me get a pouch along with me eating my emotions while being depressed.

Mines has